Clinical study confirms Phenoliva Active's anti-wrinkle efficacy

Clinical study confirms Phenoliva Active's anti-wrinkle efficacy

The results from the first clinical trials of Phenoliva Active are in. At just 0.2% concentration, Phenoliva Active achieved a significant 20% reduction in crow's feet wrinkles after 28 days in a double-blind study.

Proven Efficacy: Visible results in 4 weeks

Topical application of the eye cream formulation containing 0.2% Phenoliva Active twice daily delivered statistically significant reductions across key crow's feet parameters compared to baseline:

  • Wrinkle Area: -22.0%
  • Wrinkle Count/Number: -19.8%
  • Wrinkle Perimeter: -20.6%
  • Wrinkle Volume: -23.3%

3D topographic reconstructions confirmed a visible smoothing effect across the wrinkle matrix within just 28 days.

Picture: Measurements of anti-wrinkle efficacy after 28 days: Top row Day 0, bottom row Day 28.

Dermatologically safe and approved by consumers

Furthermore, the trial confirmed that performance goes hand-in-hand with exceptional skin compatibility:

  • Excellent Tolerance: Dermatological surveillance confirmed zero Adverse Events (AE), Undesirable Effects (UE), or Serious Undesirable Effects (SUE) across the entire panel, validating suitability for sensitive skin.
  • Substantiated Claims: The trial officially supports claims for "Clinically tested," "Dermatologically tested," and "Tolerance tested."
  • Participant Approval: Panelists reported noticeable visible improvements, with one volunteer noting, "I'm delighted, I have never tried anything so effective."

The setup of the study

The trial evaluated the topical anti-aging performance and cutaneous tolerance of cosmetic formulations containing Phenoliva Active.

  • Study Design: Double-blind, randomized split-face (hemiface) protocol.
  • Study Duration: 28 days (measurements taken at baseline/D0 and D28).
  • Participant Panel: 32 female volunteers aged 40–65 presenting mild to severe signs of facial aging (grades 1–3 on the Eiben Nielson photonumeric scale).
  • Target Area: Crow's feet wrinkle structure.

Measurement Technology: AEVA-HE 3D fringe-projection image analysis (capturing skin topography with micron precision) paired with high-resolution macroscopic photography via CameraScan.

Testing Partners: Carried out by independent laboratory Dermaclaim, with samples formulated by Phytosphere Swiss Lab.

Formulate the future of beauty

Phenoliva Active proves that upcycled, plant-derived antioxidants can deliver measurable skin-longevity results.

Interested in reviewing the full clinical documentation or testing Phenoliva Active in your next formulation? Contact our team today or get samples.

Back to blog